Leukocyte- and platelet-rich fibrin as an adjuvant to the surgical approach for osteoradionecrosis: a case report
Maluf Gustavo, Caldas Rogerio Jardim, Fregnani Eduardo Rodrigues, da Silva Santos Paulo Sergio,
소속 상세정보
( Maluf Gustavo ) - University of Sao Paulo Bauru School of Dentistry Department of Surgery, Stomatology, Pathology and Radiology
( Caldas Rogerio Jardim ) - University of Sao Paulo Bauru School of Dentistry Department of Surgery, Stomatology, Pathology and Radiology
( Fregnani Eduardo Rodrigues ) - Hospital Sirio-Libanes Departament of Oral Medicine
( da Silva Santos Paulo Sergio ) - University of Sao Paulo Bauru School of Dentistry Department of Surgery, Stomatology, Pathology and Radiology
Abstract
We present a case of osteoradionecrosis treated with leukocyte- and platelet-rich fibrin (LPRF) and surgery and followed up with clinical and tomographic investigations. A 65-year-old woman presented with pain in the posterior region of the right palate. Her medical history included cardiovascular disease and squamous cell carcinoma in the anterior region of the floor of the mouth that had been treated with intensity-modulated radiation therapy. Measurements of isodose curves showed a full dosage of 6,462.6 cGy in the anterior mandibular region, whereas that in the posterior region on the right side of the maxilla reached 5,708.1 cGy. Osteotomy was performed using rotary instruments, and debridement and placement of two LPRF membranes were also carried out. New gum tissue with no bone exposure was noted 14 days postoperatively. Tissue repair was complete, and the patient had no further complaints. During a 39-month follow-up period, the oral mucosa remained intact, and the patient was rehabilitated with a new upper denture. Since there is no consensus regarding the best protocol to treat osteoradionecrosis, LPRF might be an interesting adjuvant to a surgical approach. The use of LPRF is simple and reduces operational costs, time of handling, probability of technical failure, and associated morbidities for patients with osteoradionecrosis.
키워드
Osteoradionecrosis; Oral surgery; Cone-beam computed tomography
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